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Dr. Annie curtis

Annie Curtis has had a diverse career spanning academics, the public sector and industry.  

Annie conducted her PhD in the laboratory of Prof. Garret FitzGerald at University of Pennsylvania. This is where she was first introduced to the world of body clocks and uncovered mechanisms by which the clock controls cardiovascular function.

Annie spent time as a researcher in GlaxoSmithKline (GSK) in Philadelphia, a Scientific Programme Manager for Science Foundation Ireland (SFI) and a Medical Advisor for Immunotherapeutics with Bristol-Myers Squibb (BMS).

In 2011, she was given the opportunity by Prof. Luke O’Neill at Trinity College Dublin to return to academic research. In 2014, she was awarded an SFI Starting Investigator Research Grant (SIRG) to begin to establish an independent research group studying the impact of the body clock on the immune system.

She joined the Department of Molecular and Cellular Therapeutics and RCSI as a Research Lecturer in August 2016. In 2017, she was awarded the L’Oreal Women in Science Fellowship in 2017 and a Career Development Award from SFI.

Annie is a working mom of two little ladies, Lizzie and Faye. She is a supporter of STEM, and Women in Science. In the not too distant future she plans to read James Joyce's Ulysses, run a half marathon again, and cook something from her collection of cookbooks sitting on her kitchen shelf.



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Dr. Mariana P Cervantes Silva

Mariana obtained a Bachelor Degree in Bacteriology and Parasitology from the National Polytechnic Institute (IPN) in Mexico City (2011), and then worked as a researcher at the Angeles Hospital in Mexico City in the area of clinical immunology. In 2014 she obtained a Masters in Immunology from IPN, where she discovered the importance of mitochondria in the innate immune response.

Mariana began her PhD in Immunology in Mexico and for her last year she collaborated both with the Curtis laboratory at Royal College of Surgeons in Dublin and with the laboratory of Professor Luke O’Neill at Trinity College Dublin to complete her PhD.

She is now a postdoctoral researcher with the Curtis laboratory and her work focuses on unravelling the impact of mitochondria on the immune clock. She has presented her work at different congresses world wide and combines her scientific life with her other job of looking after her young family.


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Dr. Richard Carroll

Richie obtained his PhD from the Smurfit Institute of Genetics, Trinity College Dublin (2014) with Prof. Seamus Martin. Richie worked on the role mitophagy played in regulating apoptosis and mitochondrial health. Following his PhD, Richie undertook a postdoctoral position with Prof. Luke O’Neill investigating how metabolism can affect immune responses. During his postdoc, Richie spent one year with GSK, Stevenage. Here Richie was part of the Immunology Catalyst, an exciting new initiative by GSK to bring industrial and academic scientists together to promote scientific research.

Richie joined the Curtis Clock Lab in the Royal College of Surgeons where he works on how our molecular clock can regulate immune function through the mitochondria or metabolism.



Dr. JamIe Early

Jamie obtained his Bachelors degree in Genetics from the Smurfit Institute of Genetics, Trinity College Dublin in 2014. It was here in the lab of Dr. Matthew Campbell that he became interested in the underlying mechanisms of inflammation and first discovered the subject of circadian rhythms.

Jamie began his PhD in circadian innate immunity in the lab of Professor Luke O’ Neill in the Trinity Biomedical Sciences Institute under the supervision of Dr. Annie Curtis. By the end of his Ph.D. he was spending time between the O’ Neill lab in Trinity and the Curtis lab in Royal College of Surgeons where he focused on establishing the link between the circadian clock, antioxidant defence and inflammation.

Following his PhD, Jamie spent a year working under the supervision of Prof. David Ray, splitting his time between the Universities of Manchester and Oxford. Here, he furthered his knowledge on the role of the circadian cycle in inflammation before returning to the Curtis lab to continue his studies and to be a kept man as his girlfriend had been promoted.

Jamie has presented his work at several national and international conferences and forums, winning best speaker on three separate occasions. When not in the lab, Jamie enjoys his life as an undiscovered musical treasure in a very unsuccessful band.


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george timmons

George obtained a Bachelor of Science degree in Human Health & Disease from Trinity College Dublin in 2016 and then worked briefly as a research assistant in the area of neuroimmunology before deciding to pursue a PhD.

George began his PhD in October 2016 and his project is focused on characterizing the metabolic phenotype of clock-disrupted immune cells and the effect this has on the inflammatory state.

He has a keen interest in health & fitness and when not in the lab he can usually be found in the gym or outside. He is also the resident foodie of the Curtis Lab, knowing the best places in Dublin for a bite to eat, coffee, or cocktails.


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Lauren graduated in 2016 with a first class B.Sc. (Hons) in Analytical Science from Dublin City University (DCU). Her final year undergraduate thesis was entitled "Bismuth-based drugs as antimicrobial agents", undertaken in collaboration with researchers at RCSI. During her time at DCU she was heavily involved with the London International Youth Science Forum both as a participant and staff member, blogging about and promoting the annual event. 

Post-graduation Lauren has worked in the area of quality within the pharmaceutical industry. However, having been interested in returning to research, Lauren applied to the Irish Research Council for funding to complete a PhD, with the support of Dr. Annie Curtis and Dr. Oran Kennedy. 

Lauren was awarded a Government of Ireland Postgraduate Scholarship in 2018 to pursue research in the areas of circadian immunology and post-traumatic osteoarthritis under the supervision of Drs. Curtis and Kennedy at the Royal College of Surgeons in Ireland. 


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Shannon Cox

Shannon acquired her Bachelor’s degree in Immunology from Trinity College Dublin in 2018. She completed her undergraduate thesis project in the lab of Prof. Clair Gardiner, where she studied the role of metabolic pathways in NK cell killing. It was during this project that her interest in immunometabolism and innate immunity flourished.

She began her PhD in the Clock Lab in September 2018 investigating the link between the circadian clock, mitochondrial dynamics, and inflammation.

Excluding her interests in science, Shannon is a self-proclaimed “gamer” and Nintendo enthusiast.


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James O’Siorain

James obtained his BA (mod) in Immunology from Trinity College Dublin in 2018. He first began studying circadian rhythms during his undergraduate thesis project in the lab of Prof. Luke O’Neill, where he investigated the role of BMAL-1 in the control of the NLRP-3 inflammasome.

Fueled by a fascination with the clock, James began his PhD in the Clock Lab in September 2018 examining the relationship between clock proteins and metabolites.

He has a wide range of other interests and hobbies including music, sport, chess and travel.


Past Alumni

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Cathy Wyse

Cathy Wyse was awarded a PhD from the University of Glasgow in 2003 and spent the next 10 years working as a postdoctoral researcher at the University of Bristol, Swansea and Aberdeen, before returning to Glasgow in 2013 as a Lord Kelvin-Adam Smith research fellow, and then joining the Curtis lab in RCSI in 2016. 

Cathy's research interests are focused on understanding the effects of disruption of circadian rhythms on physiology and behaviour, and their implications for human health and well-being. She has over 40 peer-reviewed publications and has presented her work at conferences all over the world.