LAB Publications


Hudson N, Celkova L, Hopkins A, Greene C, Storti F, Ozaki E, Fahey E, Theodoropoulou S, Kenna PF, Humphries MM, 
Curtis AM, Demmons E, Browne A, Liddie S, Lawrence MS, Grimm C, Cahill MT, Humphries P, Doyle SL, Campbell M.
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy.
JCI Insight. 2019 Aug 8;4(15). pii: 130273. doi: 10.1172/jci.insight.130273. eCollection 2019 Aug 8.

Carroll RG, Timmons GA, Cervantes-Silva MP, Kennedy OD, Curtis AM.
Immunometabolism around the Clock
Trends Mol Med. 2019 May 29. pii: S1471-4914(19)30102-9. doi: 10.1016/j.molmed.2019.04.013. [Epub ahead of print]

Geiger SS, Curtis AM, O'Neill LAJ, Siegel RM.
Daily Variation in Macrophage Phagocytosis is Clock-independent and Dispensable for Cytokine Production.
Immunology. 2019 Feb 18. doi: 10.1111/imm.13053. [Epub ahead of print]


Selvarajah L, Curtis AM, Kennedy OD.
Bone Microdamage in Acute Knee Injury.
Curr Rheumatol Rep. 2018 Nov 21;20(12):89. doi: 10.1007/s11926-018-0791-8. Review.

Early JO, Menon D, Wyse CA, Cervantes-Silva MP, Zaslona Z, Carroll RG, Palsson-McDermott EM, Angiari S, Ryan DG, Corcoran SE, Timmons G, Geiger SS, Fitzpatrick DJ, O'Connell D, Xavier RJ, Hokamp K, O'Neill LAJ, Curtis AM.
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2.
Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):E8460-E8468. doi: 10.1073/pnas.1800431115. Epub 2018 Aug 20.

Wyse CA, Zhang X, McLaughlin M, Biello SM, Hough D, Bellingham M, Curtis AM, Robinson JE, Evans NP.
Circadian rhythms of melatonin and behaviour in juvenile sheep in field conditions: Effects of photoperiod, environment and weaning.
Physiol Behav. 2018 Jun 9. pii: S0031-9384(18)30296-8. doi: 10.1016/j.physbeh.2018.06.001

Wyse CA, Celis Morales CA, Ward J, Lyall D, Smith DJ, Mackay D, Curtis AM, Bailey MES, Biello S, Gill JMR, Pell JP.        Population-level seasonality in cardiovascular mortality, blood pressure, BMI and inflammatory cells in UK biobank.                            Ann Med. 2018 May 18:1-10. doi: 10.1080/07853890.2018.1472389

Romain A Colas, Patricia R Souza, Mary E Walker, Maudrian Burton, Zbigniew Zasłona, Annie M Curtis, Raquel M Marques, Jesmond Dalli
Impaired Production and Diurnal Regulation of Vascular RvDn-3 DPA Increases Systemic Inflammation and Cardiovascular Disease.
Circ Res. 2018 Feb 5. pii: CIRCRESAHA.117.312472. doi: 10.1161/CIRCRESAHA.117.312472. [Epub ahead of print]

Lyall LM, Wyse CA, Celis-Morales CA, Lyall DM, Cullen B, Mackay D, Ward J, Graham N, Strawbridge RJ, Gill JMR, Ferguson A, Bailey MES, Pell JP, Curtis AM, Smith DJ. 
Seasonality of depressive symptoms in women but not in men: A cross-sectional study in the UK Biobank cohort. 
J Affect Disord. 2018 Jan 4;229:296-305. doi: 10.1016/j.jad.2017.12.106. [Epub ahead of print] PMID: 29329063



Sutton CE, Finlay CM, Raverdeau M, Early JO, DeCourcey J, Zaslona Z, O'Neill LAJ, Mills KHG, Curtis AM.
Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.
Nat Commun. 2017 Dec 12;8(1):1923. doi: 10.1038/s41467-017-02111-0. PMID: 29234010

Zaslona Z1, Case S, Early JO, Lalor SJ, McLoughlin RM, *Curtis AM, * O'Neill LA (*both authors contributed equally).
The circadian protein BMAL1 in myeloid cells is a negative regulator of allergic asthma
Am J Physiol Lung Cell Mol Physiol. 2017 Mar 23:ajplung.00072.2017. doi: 10.1152/ajplung.00072.2017.  PMID: 28336811 (Mar 2017)

Wyse CA, Celis Morales CA, Graham N, Fan Y, Ward J, Curtis AM, Mackay D, Smith DJ, Bailey ME, Biello S, Gill JM, Pell JP. .
Adverse metabolic and mental health outcomes associated with shiftwork in a population-based study of 277,168 workers in UK biobank. 
Ann Med. 2017 Feb 6:1-23. doi: 10.1080/07853890.2017.1292045. PMID: 28166415 (Feb 2017)



McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP .
Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.  
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7778-E7787 PMID: 27856732 (Nov 2016)

Early JO, Curtis AM. .
Immunometabolism: Is it under the eye of the clock?  
Semin Immunol. 2016 Oct;28(5):478-490. doi: 10.1016/j.smim.2016.10.006. Review. PMID: 27884543 (Oct 2016)

Curtis AM, Fagundes CT. .
Understanding the Role of Cellular Molecular Clocks in Controlling the Innate Immune Response  
Methods Mol Biol. 2016;1390:301-16. doi: 10.1007/978-1-4939-3335-8_19 PMID: 26803637 (Jan 2016)



Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA .
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.  
Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7231-6. PMID: 25995365 (Jun 2015)

Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnston DG, Jiang JK, Israelsen WJ, Keane J, Thomas C, Clish C, Vander Heiden M, Xavier RJ, O'Neill LA. .
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.  
Cell Metab. 2015 Jan 6;21(1):65-80 PMID: 25565206 (Jan 2015)



Curtis AM, Bellet MM, Sassone-Corsi P, O'Neill LA. .
Circadian clock proteins and immunity.  
Immunity. 2014 Feb 20;40(2):178-86 PMID: 24560196 (Feb 2014)



Yang G, Paschos G, Curtis AM, Musiek ES, McLoughlin SC, FitzGerald GA .
Knitting up the raveled sleave of care.  
Sci Transl Med. 2013 Nov 20;5(212):212rv3 PMID: 24259052 (Nov 2013)

Curtis AM, Edelberg J, Jonas R, Rogers WT, Moore JS, Syed W, Mohler ER 3rd .
Endothelial microparticles: sophisticated vesicles modulating vascular function.  
Vasc Med. 2013 Aug;18(4):204-14 PMID: 23892447 (Aug 2013)

Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. .
Succinate is an inflammatory signal that induces IL-1β through HIF-1α.  
Nature. 2013 Apr 11;496(7444):238-42 PMID: 23535595 (Apr 2013)

Curtis AM, FitzGerald GA .
Platelet microRNAs: Novy Mir* or mired in human complexity?  
Circ Res. 2013 Feb 15;112(4):576-8. PMID: 23410874 (Feb 2013)



Curtis AM, Zhang L, Medenilla E, Gui M, Wilkinson PF, Hu E, Giri J, Doraiswamy V, Gunda S, Burgert ME, Moore JS, Edelberg JM, Mohler ER 3rd .
Relationship of microparticles to progenitor cells as a measure of vascular health in a diabetic population.  
Cytometry B Clin Cytom. 2010 Sep;78(5):329-37 PMID: 20544836 (Sep 2010)



Curtis AM, Wilkinson PF, Gui M, Gales TL, Hu E, Edelberg JM .
p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles.  
J Thromb Haemost. 2009 Apr;7(4):701-9 PMID: 19192109 (Apr 2009)



Price TS, Baggs JE, Curtis AM, Fitzgerald GA, Hogenesch JB. .
WAVECLOCK: wavelet analysis of circadian oscillation.  
Bioinformatics. 2008 Dec 1;24(23):2794-5 PMID: 18931366 (Dec 2008)

Reilly DF, Curtis AM, Cheng Y, Westgate EJ, Rudic RD, Paschos G, Morris J, Ouyang M, Thomas SA, FitzGerald GA. .
Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling.  
Arterioscler Thromb Vasc Biol. 2008 Jan;28(1):121-6. PMID: 17975121 (Jan 2008)



Curtis AM, Cheng Y, Kapoor S, Reilly D, Price TS, Fitzgerald GA .
Circadian variation of blood pressure and the vascular response to asynchronous stress.  
Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3450-5 PMID: 17360665 (Feb 2007)



Woon PY, Curtis AM, Kaisaki PJ, Argoud K, Wallace KJ, Bihoreau MT, FitzGerald GA, Gauguier D .
Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains.  
Genomics. 2006 Feb;87(2):208-17 PMID: 16376516 (Feb 2006)

Curtis AM, Fitzgerald GA. .
Central and peripheral clocks in cardiovascular and metabolic function.  
Ann Med. 2006;38(8):552-9 PMID: 17438670 (Jan 2006)



Rudic RD, McNamara P, Reilly D, Grosser T, Curtis AM, Price TS, Panda S, Hogenesch JB, FitzGerald GA .
Bioinformatic analysis of circadian gene oscillation in mouse aorta.  
Circulation. 2005 Oct 25;112(17):2716-24 PMID: 16230482 (Oct 2005)

Rudic RD, Curtis AM, Cheng Y, FitzGerald G. .
Peripheral clocks and the regulation of cardiovascular and metabolic function.  
Methods Enzymol. 2005;393:524-39 PMID: 15817310 (Jan 2005)



Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, Fitzgerald GA. .
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis.  
PLoS Biol. 2004 Nov;2(11):e377 PMID: 15523558 (Nov 2004)

Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P. .
Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.  
J Biol Chem. 2004 Feb 20;279(8):7091-7 PMID: 14645221 (Feb 2004)



Bairead E, Harmon DL, Curtis AM, Kelly Y, O'Leary C, Gardner M, Leahy DT, Vaughan P, Keegan D, O'Morain C, O'Donoghue D, Shanahan F, Parfrey NA, Quane KA. .
Association of NOD2 with Crohn's disease in a homogenous Irish population.  
Eur J Hum Genet. 2003 Mar;11(3):237-44 PMID: 12673278 (Mar 2003)