Welcome to the Curtis Laboratory

at Royal College of Surgeons in Ireland

 

Our laboratory is always watching the clock.

We are obsessed by time.

Not the passing of time but the daily cycling of time.  The reason being is that we study the body clock, which is a molecular system within cells so that they can tell the time of day.

We try to understand how this molecular clock controls our immune system.

In particular we focus on how the body clock controls cells of the innate immune system, which is our first line of defense against infection or damage.

Examples of our body clock controlling the immune system include the following:

  • Immune cells traffic around the body at certain times of day.
  • Infection causes a different immune response at one time of the day versus another.
  • Immune related conditions such as asthma, arthritis, autoimmunity and cardiovascular disease vary with time-of-day and are more severe if the innate immune clock is disrupted.
  • Disruption of our body clocks, such as with night-time shift work,  leads to increased susceptibility to inflammatory disease.

Our work has implications on how we treat inflammatory diseases but also when we treat inflammatory diseases.

The Curtis Lab is part of the Department of Molecular and Cellular Therapeutics and the Tissue Engineering Group at RCSI 

 
 
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This website was supported by The L'Oréal Foundation for Women in Science